transmembrane channel 系膜上对离子无选择性可自由进入的通道，由孔道形成蛋白(pore-forming protein；PFP)组成。孔道形成蛋白又叫作穿孔素1(proforin；p1)。因而常写成PFP/p1。胞毒作用在机体免疫防御中起着重要作用。这些效应细胞的胞浆内存在着与胞毒作用有关的PFP/p1，后者使培养的细胞发生极化(胞浆颗粒向着靶细胞移动)，并能溶解许多肿瘤细胞。肿瘤细胞可能改变PFP/p1构象，暴露出脂质结合区。Poly p1聚合成内径为1.6×10-8m(16nm)的管道，其一端可嵌入靶膜3×10-9m(3nm)深，一旦嵌入脂质双层，便形成永久性的跨膜通道。
双语例句原声例句
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虽然，囊性纤维跨膜通道调节因子基因（CFTR）突变是这种疾病的病因，但在患有CF的病人之间的不同基因的变异会改变这种疾病的严重度。
Although it is known that mutations in the CFTR gene cause the disease, variations in other genes between individuals with CF modify the severity of the disease.
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结论通过细胞膜上L型钙离子通道进行跨膜信号传递，NPY-Y1受体介导促血管平滑肌细胞增殖作用。
Through the signal pathway of L-type calcium channel on the cytomembrane, NPY-Y1 receptor could increase the proliferation of SMCs.
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胞外域结合神经递质。跨膜域形成离子通道。
It is the extracellular domain that binds neurotransmitters. The transmembrane domain forms an ion channel.
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So, that is just a quick example for some of you, you might be very familiar with ion channels, others might not know what these are, so I'll just tell you quite briefly that ion channels are these very massive transmembrane proteins.
这对你们中的某些人来说仅仅是个小例子，有些人可能已经非常熟悉离子通道这个概念了，但有些人可能还不清楚，那么就让我来简单地介绍一下离子通道,就是这些巨大的跨膜蛋白。
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