贮脂细胞(fat-storing cell,FSC,Ito)是肝脏的间质细胞,是纤维细胞的前身属结缔组织细胞系统。
Results:Turine (5~80mmol/L) markedly inhibited lipocyte,hepatocyte proliferation and collagen synthesis in a dose-and time dependent manner;20mmol/L taurine significantly suppressed the type Ⅰ and type Ⅲ procollagen mRNA expressions.
结果:在5~80mmol/L 浓度范围内,牛磺酸能显著抑制贮脂细胞、肝细胞的增殖及胶原合成,并呈时间、剂量依赖性关系;20mmol/L 牛磺酸可显著抑制Ⅰ、Ⅲ型前胶原 mRNA 的表达。
参考来源 - 牛磺酸抑制大鼠贮脂细胞、肝细胞增殖及前胶原基因表达·2,447,543篇论文数据,部分数据来源于NoteExpress
方法不连续密度梯度离心法分离纯化大鼠肝贮脂细胞。
METHODS Rat lipocyte was isolated and purified with discontinuous density-gradient centrifugation.
结果:模型组大鼠病理片呈肝纤维化变,贮脂细胞增生活跃,有较大量的IV型胶原沉积。
Result : Hepaticfibrosis appeared, fat-storing cells( FSCs) actively proliferated and the deposit of IV-collagen gradually increased in rat liver.
目的探讨组织胺及其1型受体(H1R)阻断剂、2型受体(H2R)阻断剂对贮脂细胞收缩的影响。
Objective to investigate the effect of histamine and H1 receptor (H1R) antagonist, H2 receptor (H2R) antagonist on the contractility of rat fat storing cells.
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