目的探讨凝血酶对体外培养的原代大鼠脑微血管内皮细胞(bmvec)的损伤作用及凝血酶抑制剂水蛭素的保护作用。

AIM to investigate the apoptotic effect of thrombin on brain microvascular endothelial cell (BMVEC) of cultured rat, and the protective effect of hirudin, an inhibitor of thrombin.

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血纤维蛋白原和凝血酶，自身手创伤时使血液凝固以堵塞血管破口，防止血液流失过多。

Fibrinogen and thrombin may concrete blood to jam the crevasses of blood vessels for avoiding excessive loss of blood.

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凝血酶具有血管内和血管外作用。

Thrombin has the endovascular and extravascular effects.

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