结果：第一代抗组胺药的用药频度呈下降趋势，第二代稳步上升。
Result: the DDDs of the first generation antihistamine drugs was trending to decline, but that of the second was trending to increase constantly.
结果：抗抑郁药的销售金额和用药频度呈上升趋势，分别增长24．76%和23．21%；
Result:The consumption sum and DDDs of antidepressants showed an up-trend by 24.76% and 23,21% respectively;
结论：抗菌药的用药频度，即抗菌药应用的选择性压力，是影响细菌耐药性变异最主要的因素之一。
Conclusion; the DDDs, that is the selective pressure of the antibacterial usage, is one of the main influencing factors of the variation of drug resistance.
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