在人体中，Kv 1.1对应的基因突变与自发性疾病发作，异常肌肉运作，和肌肉协调问题有关。
In humans, mutation of the gene for Kv1.1 has been associated with spontaneous seizures, abnormal muscle movements, and motor coordination problems.
在小鼠模型中，GNA11突变诱导了自发转移性肿瘤，激活了丝裂原活化蛋白激酶途径。
Mutations in GNA11 induced spontaneously metastasizing tumors in a mouse model and activated the mitogen-activated protein kinase pathway.
要充分利用突变小鼠作为研究模式，则需要诱发突变或自发基因突变之正确基因表现型特征。
Making full use of mutant mice as research models requires correct characterization of the phenotypes that result from induced or spontaneous genetic mutations.
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