目的建立急性脑缺氧缺血的动物模型。

Objective To replicate the acute hypoxic ischemic brain damaged animal model.

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背景：幼鼠脑缺氧缺血后，脑组织水肿加重，脑组织中一氧化氮及丙二醛水平增高。

BACKGROUND: After cerebral tissue ischemia and anoxia in young rats, the cerebral edema gets serious, and the levels of nitric oxide (no) and malondialdehyde (MDA) decrease.

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结果表明，对小鼠抗脑缺氧、抗急性脑缺血及抗急性脑栓塞形成等均有显著的保护作用，其药效与腹腔注射尼莫地平溶液接近，显著优于灌胃给药。

Nimodipine liposomes could effectively protect the brain against damage, and were comparable to that after IP nimodipine injection but significantly better than that after ig administration.

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