The intermediate C(N-4-4-(3-nitro-phenyl)-piperazin- 1-yl-butylphthalimide) can be obtained through nucleophilic substitution reaction from phthalimide potassium salt, 1,4-dibromobutane and intermediate A, and then you can get the comound D(4-4-(3-nitro-phenyl)-piperazin-1-ylbutylamine) following its hydrazinolysis.
以邻苯二甲酰亚胺钾盐、1,4-二溴丁烷、中间体A为起始原料,经过亲核取代反应制得化合物C(N-4-4-(3-硝基苯基)哌嗪基-1-丁基邻苯二甲酰亚胺),然后经肼解反应制得中间体D(4-4-(3-硝基苯基)哌嗪基-1-丁基胺)。
参考来源 - 新型抗抑郁药物Prx·2,447,543篇论文数据,部分数据来源于NoteExpress
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