目的：探讨非靶位基因突变及外膜通透性改变对大肠杆菌喹诺酮类耐药和多重耐药的影响。
Objective To investigate the impact of non target gene mutations and reduced permeability of the outer membrane on quinolone resistance and multiple antibiotic resistance (mar) in Escherichia coli.
目的探讨大肠埃希菌靶位基因突变对喹诺酮类药物耐药的影响。
Objective To investigate the effects of target gene mutations on the quinolones resistance in Escherichia coli.
结论铜绿假单胞菌的耐药性日趋严重，两类拓扑异构酶基因突变和泵出机制形成了铜绿假单胞菌对喹诺铜类药物耐药的主要机制。
The resistance to quinolones in clinical isolates of Pseudomonas aeruginosa is due to the mutations of two types of topoisomerase plus efflux pump.
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