天然抗生素的结构进行适当的修饰可改善其性能，是探索开发新药的有效途径之一。
c02021 Key words Natural product molecules, Enzyme, Catalysis, Modification, Combinatorial biocatalysis [gap=153]关键词 天然产物 酶 催化 结构修饰 组合酶催化
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Combretastatin A4类似物研究新进展 - 中国新药杂志 关键词： CA4；抗肿瘤；微管蛋白抑制剂；结构修饰 [gap=514]Key words： CA4; antitumor; tublin inhibitor; structure qualification
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天然抗癌药紫杉醇及其半合成类似物的研究进展 关键词】 紫杉醇；半合成；结构修饰 [gap=344]Key words】 Paclitaxel;Semi-synthesis; Structural modify
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To natural products as lead compounds, their structural modification, adaptation to new synthetic anti-cancer drugs are currently a hot research.
将天然产物作为先导化合物,对其进行结构修饰、改造进而合成新的抗肿瘤药物是目前研究的热点。
参考来源 - 齐墩果酸衍生物的合成及其结构表征However,its poor solubility prevented itself from clinical use. In this paper,the distribution,antitumo activity,structure modification,as well as the advances in R&D of oridonin derivatives were reviewed.
对冬凌草甲素进行结构修饰,改善其水溶性得到了部分抗肿瘤活性更强的冬凌草甲素衍生物。
参考来源 - 冬凌草甲素的研究进展The prevalence of antibiotic resistance in bacterial pathogens has been becoming a serious worldwide health problem, several classes of novel chemical modification compounds such as ketolides and 4"-carbamate macrolides derivatives have good antibacterial activity against macrolide-resistant bacteria.
当前世界范围内耐药菌问题日益严峻,采用化学方法对大环内酯进行结构修饰已经获得了几类对耐药菌有良好抗菌活性的化合物,如酮内酯类和4”-氨基甲酸酯类化合物。
参考来源 - 十五元氮杂大环内酯类新化合物的合成与抗菌活性研究Using EGCG as a lead compound, in order to improve the fat-soluble and bioavailability of acetylated EGCG derivatives, the development of high-activity and high application value product by structural modification is an important topic.
以EGCG为先导化化合物,通过结构修饰开发具有较高活性和应用价值的EGCG乙酰化衍生物,以改善脂溶性,提高生物利用度,是当前研究领域的一个重要课题。
参考来源 - 乙酰化EGCG衍生物的合成、纯化及应用特性研究This thesis consisted of two sections, the synthesis of T614's derivatives and studies on the structure modifying of Aspirin and its derivatives in carbohydrate.
本论文由两部分组成，即T614衍生物的合成和阿司匹林及其衍生物的糖基化结构修饰研究。
参考来源 - T614衍生物的合成和阿司匹林及其衍生物的糖基化结构修饰研究·2,447,543篇论文数据，部分数据来源于NoteExpress
本论文研究了具有生物活性的芪类化合物的合成与结构修饰。
In this thesis, the synthesis and its structure modification of bioactive stilbenes have been studied.
目的：对天然五环三萜进行结构修饰，寻找新型糖原代谢调控药物。
Aim: to search for novel modulators of glycogen metabolism through structural modifications of natural pentacyclic triterpenes.
目的：探讨岩白菜素经结构修饰得到的衍生物以及它们的抗肿瘤细胞的活性。
Objective: To investigate the derivants of bergenin through structural modification and their activity of anti-tumor cells.
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