• cytotoxic drug - 引用次数：3

  Membrane transport proteins such as P-glycoprotein, multidrug resistance accosiated protein, etc can be active as drugs excavating pump, and lower the concentration of the cell cytotoxic drug and cause MDR.

  以P -糖蛋白( P-glycoprotein , P-gp)、多药耐药相关蛋白(multidrug resistance accosiated protein ,MRP1～7)等为代表的膜转运蛋白作为药物排出泵,可以导致胞内的细胞毒药物浓度降低,使肿瘤细胞对多种抗肿瘤药物产生耐药。

  参考来源 - BCRP、GST

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