纤维素样坏死(fibrinoid necrosis)是发生在间质、胶原纤维和小血管壁的一种坏死。光镜下,病变部位的组织结构消失,变为境界不甚清晰的颗粒状、小条或小块状无结构物质,呈强嗜酸性,似纤维蛋白,有时纤维蛋白染色呈阳性,故称此为纤维蛋白样坏死。以往误认为上述病变是一种可逆性改变,称为纤维素样变性(fibrinoid degeneration),并且沿用至今。纤维素样坏死常见于急性风湿病、系统性红斑狼疮、肾小球肾炎等过敏反应性疾病。
恶性高血压导致小动脉纤维素样坏死。
Malignant hypertension leads to fibrinoid necrosis of small arteries as shown here.
结节中央为纤维素样坏死物,四周围绕着上皮样细胞与其它单核细胞。
They can occasionally appear in visceral organs. There is a central area of fibrinoid necrosis surrounded by pallisading epithelioid macrophages and other mononuclear cells.
恶性高血压导致小动脉纤维素样坏死。动脉损伤引起粉红色纤维素坏死物形成,因此称为纤维素样坏死。
Malignant hypertension leads to fibrinoid necrosis of small arteries as shown here. The damage to the arteries leads to formation of pink fibrin — hence the term "fibrinoid".
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