方法：测定破伤风类毒素聚乳酸微球免疫动物后1年中动物血清抗体反应及疫苗制剂的生物利用度。
Methods: The antibody levels elicited by microsphere formulations in mice for 1 year were examined, and the bioavailability of microsphere formulations was calculated.
研究不同剂量及不同白喉类毒素纯度引起的迟发型超敏反应的状况，用于指导疫苗的生产，提高疫苗的质量。
The delayed hypersensitivity induced by the diphtheria toxoid with different purity and dose was investigated to guide the vaccine production and improve the vaccine quality.
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