突变型基因为DNA分子中发生碱基对的增添、缺失或改变，而引起的基因结构的改变。
突变型p53基因的编码蛋白不但丧失上述功能，甚至出现了促使细胞癌变的作用。
The protein(P53) encoded by mutant p53 gene (mtp53) not only losses these functions, but also make cell malignant transformation.
结论成功构建了PIG - A基因逆转录病毒载体，感染突变型k562细胞后可以提高其CD 59的表达。
Conclusion the retrovirus vector containing the PIG-A gene was successfully constructed and the expression of CD59 on the mutant K562 cells could be increased.
结论野生型和突变型PRPF31基因真核表达载体的构建，为研究PRPF31基因突变引起视网膜色素变性的机制奠定了基础。
Conclusion Construction of the eukaryotic expression vectors of wild type and mutant PRPF31 genes is basic work for research on the mechanisms of retinitis pigmentosa caused by PRPF31 mutation.
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