一种化学基团，指一分子磷酸与两个醇（羟基）酯化形成的两个酯键。磷酸二酯键成了两个醇之间的桥梁。例如前一个核苷酸的羰基中的3碳上'—OH（羟基）和后一个核苷酸的5'—磷酸基形成酯键，此处的磷酸基同时与前后两个羟基形成酯键，故称磷酸二酯键。依次连下去，形成多核苷酸链，即核酸大分子链。
Meanwhile, research about using rare-earth ions and their complexes as artificial restriction enzymes has gotten more and more recognition, as they can hydrolytically cleave the phosphate diester bond in nucleic acid, and their cleavage efficiencies are higher.
与此同时,有关稀土及其配合物作为人工酶的研究越来越受到人们的重视,因为它们能以水解方式断裂核酸中的磷酸二酯键,并且断裂效率较高。
参考来源 - 双核金属配合物的合成、表征及其与DNA的作用研究·2,447,543篇论文数据，部分数据来源于NoteExpress
当时只能证明rna可以切割和连接磷酸二酯键。
At that time, it had only been demonstrated that RNA could cleave or ligate phosphodiester bonds.
近年来，人类在研究磷酸二酯键水解断裂的化学模拟方面已经取得了很大进展。
In recent years, a great progress has been made in chemical mimic for the hydrolytic cleavage of phosphodiester bond by using bioinorganic methods.
应用推荐