直接致癌物(direct carcinogen)不需在体内经过代谢活化就能直接诱发肿瘤的物质。数量较少，一般多为烷化剂，化学性质活泼，在环境下易被分解多在体内能释放出亲电子物，同生物大分子受体结合。如芥子气、氮芥、环磷酰胺、溶肉瘤素和铬酸盐、羰苯镍、亚砷酸钠、石棉、亚硝基脲、亚硝基胍、二氯甲醚等。
制备食品时的烟熏和直接干燥工序在燃烧过程中形成的部分多环芳烃可能是人类致癌物。
Parts of PAH are possible human carcinogens formed during the combustion of fuel both in the smoking and in the direct drying processes involved in the preparation of food.
采用不同方法的各类调查一致说明镉(国际癌症研究机构第1类致癌物)直接从烟草转化为烟雾。
Various investigations using different methodologies consistently indicate that cadmium (an IARC Type 1 carcinogen) transfers linearly from tobacco into smoke emissions.
这被认为是有史以来的直接用于人体的致癌物最大剂量。
This is believed to be the largest dose on record of a pure carcinogen administered directly to people.
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