中文名称:盐酸雷莫司琼 中文别名:(-)-(R)-5-[(1-甲基-1H-吲哚-3-基)羰基]-4,5,6,7-四氢-1H-苯并咪唑盐酸盐 英文名称:Ramosetron Hydrochloride 英文别名:Ramosetron HCl; (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]methanone hydrochloride (1:1) CAS:132907-72-3
【正文快照】： 盐酸雷莫司琼(ramosetron hydrochloride)是一种新型高选择性5-HT3受体拮抗剂,用于治疗和预防化疗药物引起的恶心、呕吐等消化道症状。
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注射液 通用名称：盐酸雷莫司琼 英文名称：Ramosetron Hydrochloride Injection 汉语拼音：Yansuan leimosiqiong zhusheye 编辑本段 规 格 2ml:0.3mg 编辑本段 批准文号 国药准字H20
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... 盐酸西替利嗪 Cetirizine Hydrochloride 盐酸雷莫司琼Donepezil Hydrochloride 氯诺昔康Lornoxican ...
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In the synthesis process of N-methylindole,the condition of the reaction was optimized, and the yield of product was improved. The intermediate pyrrolidin-1-yl(4,5,6,7-tetra-hydro-benzo imidazol -5-yl ) methanoneand the other intermediate N-methylindole was used to produce target compound recemic ramosetron hydrochloride.
在中间体N-(4,5,6,7-四氢苯并咪唑-5基)吡咯盐酸盐和N-甲基吲哚的基础上进一步合成得到目标产物盐酸雷莫司琼。
参考来源 - 外消旋盐酸雷莫司琼的合成研究·2,447,543篇论文数据，部分数据来源于NoteExpress
目的探讨盐酸雷莫司琼注射液安全性，为临床用药提供参考。
Objective It's to provide reference for clinical utilization that the safety of ramosetron hydrochloride injection was studied.
结果盐酸雷莫司琼注射液对豚鼠无致敏作用，对家兔红细胞无明显体外溶血及致凝集作用，对家兔血管无明显刺激作用。
Results Ramosetron hydrochloride injection has no hypersensitivity to guinea pig, no hemolysis and agglomeration to red blood cells of rabbit, no obvious stimulation to blood vessels of rabbit.
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