皮肤硬化是指皮肤发生局限性或弥漫性变硬或硬结的病理变化，多为真皮和皮下组织水肿、细胞浸润和胶原纤维增生所致。皮肤硬化常见于结缔组织疾病、代谢性疾病、物理性皮肤病变以及肿瘤与某些遗传病。皮肤硬化的病因很多，应尽早找出病因，及时针对病因进行治疗。
该病和硬皮病的临床表现很相似，都是以局限性皮肤硬化为主要皮损表现。
Its primary clinical manifestation is localized sclerosis of the skin, which is very similar to scleroderma.
这些都是常用的治疗条件，如硬皮病可导致广泛的疤痕和硬化的皮肤。
These are often used to treat conditions such as scleroderma that can cause extensive scarring and hardening of the skin.
硬斑病是一种结缔组织病，其特征是皮肤因胶原沉积过多而硬化和增厚。
Morphoea is a connective tissue disorder characterised by hardening and thickening of the skin due to an increased collagen deposition.
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