目的通过星点设计-效应面法优化替硝唑结肠靶向生物黏附片处方。
OBJECTIVE To optimize the formulation of tinidazole colon-targeted bioadhesive tablets by the central composite design-response surface methodology (RSM plus CCD).
目的研制三七总皂苷生物黏附片，考察其体外释药动力学、对离体肠黏膜的黏附力。
OBJECTIVE To prepare the Panax Notoginseng Saponines (PNS) bioadhesive tablets, and to study their release kinetics and bioadhesive tablets force to rabbit small intestine in vitro.
结论口颊黏附片的生物黏附性与体外释药行为具有一定的相关性，通过调整处方可筛选出生物黏附性和体外释药均较理想的处方。
CONCLUSION the adhesive property of the tablets and the release behavior of drug are relevant. Also, the formulation of buccal adhesive tablets is optimized by adjusting the composition.
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