烷化剂(Alkylating Agents)是一类化学性质高度活泼的化合物,属于细胞毒类药物,又称生物烷化剂(Bioalkylating Agents),在体内能形成碳正离子或其他具有活泼的亲电性基团的化合物,进而与细胞中的生物大分子(如DNA、RNA、酶等)中含有丰富电子的基团(如氨基、巯基、羟基、羧基、磷酸基等)发生共价结合,使其丧失活性或使DNA分子发生断裂,导致肿瘤细胞死亡,抗肿瘤活性强。
烷化剂 alkylating agent ; Alkylating agents ; alkyl agent
硅烷化剂 silanizing agent
烷化剂亚硝基胍 nitrosoguanidine ; NTG
烷基化剂 [有化] alkylating agent
甲烷化催化剂 Methanation Catalyst ; catalysts for methanation ; water gas methanation catalyst
烷化剂甲璜酸甲酯 methyl methanesulfonate ; MMS
硅烷化试剂 BSTFA ; Silylation ; Slilyl Reagents ; silane blocking agent
甲硅烷基化剂 silylating agent
环氧乙烷银催化剂 silver catalyst for ethylene oxide
烷醇铝催化剂 aluminium alkoxide catalyst
Alkylating agents especially the N-Nitroso alkylating agents are widely present in the environment and DNA alkylation seems to be a common event. The monofunctional alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), a model chemical of .
烷化剂尤其是N-亚硝基类烷化剂广泛存在于环境中,引起DNA烷基化。
参考来源 - 哺乳细胞暴露于化学致癌剂MNNG的候选生物标记物的筛选和鉴定The chemotherapy of tumor is one the three general therapeutics in clinic therapy, now chemotherapy is developed into many systems which includes alkylating agent、 antimetabolite、 biologic response regulator.
肿瘤的化疗是临床治疗的三大常规疗法之一,目前化疗已经发展成为包括烷化剂、抗代谢剂、分化诱导剂、生物反应调节剂等多个体系。
参考来源 - 抗肿瘤抗生素S·2,447,543篇论文数据,部分数据来源于NoteExpress
将烷化剂类药物和放射治疗联合使用会提高不育症风险。
The combination of alkylating drugs and radiation therapy increases the risk for fertility problems.
因此,无论是烷化剂和邻苯二甲酸衍生穿透胎盘,是危险的胚胎。
Hence, both the alkylating agent and the phthalate derivative penetrate placenta and are dangerous for embryos.
本课题以蜜糖和十二烷基二甲基叔胺为原料,选择环氧氯丙烷作为季铵化反应的烷化剂。
This new synthesis method of humectants used honey and di-methyl-dodecyl amine as material to produce a quaternary surfactant.
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