Among all of these protocols, combining blockade of co-stimulatory signals with donor specific bone marrow transplantation to establish allogeneic mixed chimerism is the one that has the best prospect to be used in the clinic.
其中，阻断T细胞活化的共刺激信号联合供者特异性骨髓移植建立异基因混合嵌合体，是目前所知最具临床应用前景的一种耐受诱导策略。
参考来源 - 腺病毒介导CTLA4Ig基因转染联合供者特异性细胞输注诱导小鼠皮肤移植耐受的研究ObjectiveTo establish durable and stable mixed chimeras and explore its effect on prevention and cure of acute graft-versus-host disease after xenogeneic bone marrow transplantation.
目的 为了建立持久稳定混合嵌合体（MC）模型及进一步探讨其对异种骨髓移植（XBMT）后急性移植物抗宿主病（aGVHD）的防治作用。
参考来源 - 持久稳定混合嵌合体诱导免疫耐受在异种骨髓移植中作用的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
造血干细胞混合嵌合体是指两个不同基因型个体的骨髓造血干细胞共存的一种状态。
Mixed hematopoietic chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different individuals coexist.
由两个物种的细胞混合而诞生的动物，其科学术语唤作嵌合体。
The scientific term for an animal with mingled cells from two species is chimera.
嵌合体由两种或两种以上有不同基因结构的组织所构成的有机体，由于突变、嫁接或来自不同合子的细胞群体相混合而产生。
An organism consisting of two or more tissues of different genetic composition, produced as a result of mutation, grafting, or the mixture of cell populations from different zygotes.
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