本品为细胞周期非特异性药，对处于G1-S边界，或S早期的细胞最敏感，对G2期亦有抑制作用。本品进入人体后，其分子从氨甲酰胺键处断裂为两部分：一为氯乙胺部分，将氯解离，形成乙烯碳正离子，发挥烃化作用，致使DNA链断裂，RNA及蛋白质受到烃化，这些主要与抗瘤作用有关
...明医生文章_阿亮医生 tine ACNU) 、卡莫司汀( bischloro2nit rosourea ,BC2NU) 、洛莫司汀(chlorethyl cyclohexyl nit rosourea ,CCNU) 、甲基苄肼( Procarbazine , PCB) 、甲氨喋呤( methot rexate ,..
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洛莫司汀胶囊 Lomustine Capsules ; CeeNU
But there is not diffence in complementary between the two groups. Conclusions Lumostine chemotherapy is an effective treatment after Gamma Knife radiosurgery for the cerebral meteastases and more effectual than the only radiosurgery.
结论 伽玛刀联合洛莫司汀治疗脑转移瘤是一种有效的措施，效果较单纯伽玛刀佳。
参考来源 - 伽玛刀联合洛莫斯汀治疗脑多发转移瘤的临床研究·2,447,543篇论文数据，部分数据来源于NoteExpress
采用逆相蒸发法制备洛莫司汀脂质体。
Lomustine liposomes were prepared by the reversed-phase evaporation method.
目的制备洛莫司汀热敏脂质体并考察其体外抗肿瘤活性。
OBJECTIVE To prepare Lomustine thermo-sensitive liposomes (CCNU-TSL) and investigate the anti-tumor activity in vitro.
结论洛莫司汀热敏脂质体在相变温度时，体外释药明显增加，体外抑瘤效果明显提高。
CONCLUSION the drug release percents and the tumor control rates of CCNU-TSL are improved significantly compared with lomustine solution in vitro.
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