...acid;Synthesis 胡椒丙烯酸(piperonylacrylic acid 1)是血管紧张素转化酶(ACE)和肽链内切酶(NEP)双重抑制剂法西多曲(Fasidotril)的关键中间体 ..
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The synthesis routes of Fasidotril were researched in this thesis. Catechol was selected as the raw material, through cyclization, chloromethylation, alkylation, hydrolysis, Mannich-elimination reaction, addition, anhydration and condensation, then the target product Fasidotril was prepared in total yield 17.5%.
本文对法西多曲的合成方法进行了研究,以邻苯二酚为原料,通过环合、氯甲基化、烷基化、水解、Mannich-消去反应、加成和脱水缩合共7步反应合成了法西多曲,总收率为17.5%。
参考来源 - 法西多曲的合成·2,447,543篇论文数据，部分数据来源于NoteExpress
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