结果：动物表皮有一层角化过度的角质层，毛干消失，毛球结构不正常，毛囊内为一些角化物质，有的变为空囊腔。

Results: There is a excessively keratinized layer in the animal epidermis, loss of hair shaft, abnormal structure of hair bulbs.

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先证者双肘膝关节毛囊角化性丘疹，足趾及跖部灶性胼胝样角化过度，20甲营养不良。

Proband also had special clinical feature including follicular hyperkeratosis on the elbows and knees, and onychodystrophy of 20 nails as well.

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其发病机理尚不完全清楚，主要包括：皮脂分泌过多、毛囊皮脂腺导管的过度角化、痤疮丙酸杆菌增殖、过度的免疫反应等。

The pathogenesis is not clear, including: excessive secretion of sebum, follicle sebaceous gland duct hyperkeratosis, Propionibacterium acnes proliferation and excessive immune reactions ect.

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