疾病后期，核内的RHDV颗粒通过破损的核膜或核崩解向细胞浆扩散。

After manifestative stage of the disease RHDV gradually diffused from nucleus into cytoplasm and reached a maximum in cytoplasm at agonal stage.

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肌核改变可能是IBM的病因基础，镶边空泡和肌浆内包涵体有可能来自于崩解的肌核。

Also the results suggested that myonuclear alterations might lead to the basic genesis of IBM.

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