整联蛋白(integrin)又称整合素,整联蛋白属整合蛋白家族,是一类普遍存在于脊椎动物细胞表面,依赖于Ca2+或Mg2+的异亲型细胞黏附分子,介导细胞和细胞之间以及细胞和细胞外基质之间的相互识别和粘附,具有联系细胞外部作用与细胞内部结构的作用。
...摘要] 一种[6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-磺酰氨基]-丙酰胺衍生物,一种式(1)的化合物对CAMs及白整联蛋白(Leukointegrins)的相互反应具有良好的抑制效果,并因此可用于治疗炎症疾病。
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The isolated cells were cultured and then identified by detecting the expression of β1-integrin, CD34 and α6-integrin by immunohistochemical assays.
免疫细胞化学检测培养细胞中β1-整联蛋白、CD34和α6-整联蛋白的表达。
参考来源 - 大鼠毛囊干细胞的纯化培养鉴定及其生物学特性Conclusion:1. cloned the completeβ1 Gene of foot-and-mouth disease virus integrin receptor and successfully constructed its euokaryotic expression recombinant plasmid pCDNAβ1.2.
结论:克隆了口蹄疫病毒整联蛋白受体β1基因的全基因组,并成功构建了其真核表达载体。
参考来源 - 口蹄疫病毒整联蛋白受体β·2,447,543篇论文数据,部分数据来源于NoteExpress
本发明涉及化合物及其衍生物、它们的合成方法以及它们作为整联蛋白受体拮抗剂的用途。
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists.
氨基核苷嘌呤霉素诱导肾病变是人原发性肾病综合症的模型,抑制培养的肾小球上皮细胞整联蛋白的表达。
Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing expression of integrin expression in cultured glomerular epithelial cells.
整联蛋白是一类重要的细胞表面分子,除介导细胞与胞外基质及细胞间的粘附外,还对细胞的识别、生长和分化具有重要作用。
Integrins are an important cell surface molecules that contribute to a variety of biological functions, including mediate cell and extracellular matrix and cell-cell adhesion.
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