差：大多数散装原料储存在设计拙劣的缸或容器中，难以保持卫生的条件。
Poor: Most bulk ingredients stored in tanks or vessels of poor design which are difficult to maintain in a sanitary condition.
药物制剂的批准和销售之后，生产散装的原料药方面可能会发生大的改变。
After approval and marketing of a pharmaceutical product, significant changes may be made in manufacturing the bulk drug substance.
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