第一次爆发是在公元6世纪，拜占庭国王查士丁尼统治时期，瘟疫通过运粮船，从埃及蔓延到了当时拜占庭首都君士但丁堡。
The first appeared in the 6th century during the reign of the Byzantine emperor Justinian, reaching his capital, Constantinople, on grain ships from Egypt.
其中有些手稿已经遗失了，有些则保存在拜占庭帝国的首都君士坦丁堡，有些则被翻译成阿拉伯文并保留在了阿拉伯世界。
Those were lost but some of these manuscripts remained in the Byzantine world of Constantinople and some were translated by the Arabs and preserved in the Arabic world.
离其不远的奥赫里德曾是保加利亚帝国的首都，当时整个帝国由特萨萨缪尔统治着，后来拜占庭帝国侵占了这片土地。
The nearby town of Ohrid was once the capital of a sprawling Bulgarian empire ruled by Tsar Samuel and later conquered by the Byzantines.
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