目的对氨基糖苷类抗生素生物合成基因的研究进展作一综述。

Objective To review the studies on the biosynthesis genes of the aminoglycoside antibiotics.

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组合生物合成是在抗生素产生菌的次级代谢产物合成途径中涉及到的一些酶的编码基因之间的互换，从而产生许多新的“非天然的天然化合物”。

Combinatorial biosynthesis can produce new "unnatural" natural products through exchange of genes encoding the enzymes involved in secondary metabolites biosynthesis pathway in antibiotics producers.

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本发明还涉及螺旋霉素生物合成途径的基因用于构建能够导致新抗生素合成或螺旋霉素衍生形式合成的突变体的用途。

The invention also concerns the use of genes in spiramycin biosynthesis process for constructing mutants capable of leading to synthesis of novel antibiotics or derivative forms of spiramycin.

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