我认为重大问题必须找我商量。

I expect to be consulted about major issues.

《牛津词典》

我是在一个不正常的家庭里长大的，所以乱发脾气是我的一大问题。

Because I grew up in a dysfunctional family, anger is a big issue for me.

《牛津词典》

我认为这也是一个需要我们高度关注的大问题。

I think this is also a big problem which needs our great attention.

youdao

If it were just a little bit different I could say, all right, I have a different approximation. But when it's this different, something is wrong. Right?

但是如果仅仅有点差异的话,我可以认为没什么大问题,我得到了一个不太一样的估算，但这确实有差异，出问题了对不对？

麻省理工公开课 - 计算机科学及编程导论课程节选

That's a big problem a lot, I think in group projects

我觉得这是很多团队项目当中的大问题，

怎么协调意见冲突 - SpeakingMax英语口语达人

Using the material you've learned in class, you'll be expected to answer some big questions for an 8-page final paper that you'll turn in at a date to be assigned.

运用你在课堂上学到的材料，在8页论文中回答某些大问题,然后准时交给我。

耶鲁公开课 - 新约课程节选