忧郁发作的时候，又会情绪低落、无助无望，甚至觉得活著没有价值和意义，甚或自杀。
During the Major Depressive Episode, patients feel so depressed, helpless, and hopeless that they consider life is worthless or meaningless. These feelings may even lead to suicide.
Barbara Elman, 79岁，一个布鲁克兰的寡妇同时也是祖母，她经历过好几次忧郁症的发作，她形容说“很可怕，很可怕，”让周围的人无法忍受的严重。
Barbara Elman, 79, a Brookline widow and grandmother who has experienced several bouts of depression, describes it as "awful, awful," so crippling that being around people is unbearable.
而且没有一项研究发现月亮圆缺与人类忧郁症或颠狂症的发作有直接联系。
Also, no research has yet found a direct link between the phases of the moon and attacks of depression or mania.
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