孕期及哺乳期锌缺乏损伤脑组织微管聚合机理研究 关键词：锌缺乏 脑功能 微管蛋白 微管聚合 [gap=1743]Key words:zinc deficiency, brain function, tubulin, microtubule polymerization
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促微管蛋白聚合蛋白 TPPP
Detailed in vitro analysis demonstrated that LJK-11 inhibited microtubule polymerization. The mode of action of LJK-11 on microtubule polymerization resembles most closely that of colchicine.
体外微管结合实验证实了LJK-11抑制微管聚合，并且其作用方式与秋水仙素类似。
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将目标化合物进行了抗肿瘤体外试验和微管聚合试验。
Target compounds 4 and 5 were tested in a tubulin assembly assay, and in an in vitro cytotoxicity assay(KB cell line).
结果5f能抑制反应体系吸光值升高，提示它对微管蛋白聚合具有抑制作用并能抑制其解聚。
Results 5f decreased the Absorption values of the reaction system. and markedly inhibited not only tubulin polymerization but also tubulin depolymerization.
研究表明，TBZ可能通过抑制微管蛋白聚合来影响染色体正常分离，诱发非整倍体。
The result suggested that TBZ may induce aneuploidy by the pathway of tubulin polymerization inhibition which is able to lead to chromosomal malsegregation.
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