事实证明，作为一种特异的分子伴侣，HSP90除在细胞正常生长和应急保护中具有重要生理功能外，还与信号传导、细胞周期调控、激素应答等细胞内重要生理过程有关。
In fact, as a specific molecular chaperone, HSP90 proteins are possibly involved in many important physiological processes such as signal transduction, cell cycle regulation and hormone response.
细胞对DNA损伤作出应答的一个重要过程是检查点活化(检查点激酶CHK1和CHK2使关键蛋白磷酸化，从而阻止正常的细胞周期。)
An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
进一步的研究表明它们事实上是DNA损伤-应答激酶，不仅仅是调控细胞周期的检查点。
However, further studies have indicated that they are actually DNA-damage-response kinases, regulating more than just cell-cycle checkpoints.
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