广防己,中药名。是一种多年生落叶缠绕藤本。根圆柱形,茎纤细,有略扭曲的纵条纹。在中药中通常用其木质根干燥炮制后入药,具有利水消肿,祛风止痛之功用。因其含有马兜铃酸,国家药监局下发通知,2004年9月30日起,广防己不再用作药品生产。根据通知要求,凡含广防己的中成药品种,生产企业必须在9月30日前将处方中的广防己用防己替换。
Since Belgian scholars reported that sufferers had taken Kangfangchi and Cortex magnoliae officinalis medicine for banting and suffered from nephrotoxicity in 1993,subsequently it was finded to be caused by aristolochic acid. So it was defined aristolochic acid nephrop athy(AAN).
自从1993年比利时学者报道,患者在服用含广防己和厚朴的中草药减肥治疗后,出现进行性肾损害,后发现是含马兜铃酸成分所致肾毒性,将此定义为“马兜铃酸肾病”(aristolochic acid nephropathy,AAN)。
参考来源 - 黄芪与广防已优化组合对大鼠急性肾毒性保护作用的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
结果:与空白组对照,大剂量广防己组尿AKP明显升高(P<0.05);
Results:Compared to blank group, the concentrations of AKP were significantly higher(P<0.05) in high dosage group.
目的: 观察广防己醇提取物(RAFE)急性以及不同剂量的RAFE对肾脏慢性毒性。
Objective: To observe the acute and chronic renal toxicity induced by Radix Aristolochiae Fangchi Extract(RAFE) in different doses in rats.
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