主要付反应是局部刺激性较大。
方法：按《新药审批办法》有关外用药局部刺激性研究的规定进行。
Methods: the methods in the "Approval Provision of New Drug" were used.
本实验显示新型根管充填剂复方牡蛎粉无细胞毒性、无基因毒性、无皮肤致敏性以及局部刺激性，具有良好的生物相容性。
The new root canal filling material showed no detected cytotoxic, genotoxic effect, potential of skin sensitization and topical irritation and has good biocompatibility.
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