...疫活性胰岛素,同时检测空腹血脂、游离脂肪酸、脂联素、超敏C反应蛋白（hs-CRP）、血清内皮素（SET）,留取晨尿测定尿内皮素（UET）与尿微量白蛋白（U-MA）,记录糖尿病家族史并观察血压、身高和体重,测定肱动脉休息时、加压及服用硝酸甘油后的内径变化.
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方法：链尿佐菌素（STZ）腹腔注射诱导建立DN大鼠模型，检测体重、血糖、内皮素（ET）和一氧化氮（NO）的变化。
Method: The rat model of DN was constructed by intraperitoneally injected streptozocin(STZ), and the body weight, blood glucose, endothelin(ET) and nitric oxide(NO) were measured.
目前已知一类称为内皮素受体A拮抗剂的药物能减少蛋白尿。
It's also known that a new class of drugs called endothelin a receptor antagonists reduce protein in the urine.
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