尽管遇到很多困难，马克从未放弃对知识的追求。
Despite the hardship he encountered, Mark never gave up the pursuit of knowledge.
在电影中，尽管遇到很多困难，珍爱仍然坚持抚养她的孩子。
In the film, Precious insists on keeping her children all the time though she gets involved in trouble.
嗯，我想告诉那些在生活中遇到挑战的人，尽管他们的生活有很多困难，但是他们还是能成就很多事。
Well, I want people who have challenges in their lives to believe that despite their difficulties they can still accomplish a lot.
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