当疼痛持续不消时，会造成显著的变化：脊髓神经元变得极度敏感，对微弱的刺激也产生放电反应。
When pain is unremitting, dramatic changes follow: spinal cord neurons become hypersensitive and start firing in response to weak stimuli.
结果表明，理气止疼方剂金铃子散对冰醋酸以及甲醛-足跖炎性疼痛反应(F、S相)均有显著抑制作用，但对热刺激疼痛反应的抑制作用没有统计学差异。
JLZS showed a potent inhibitory activity on the acetic acid induced writhing and formalin induced f, s phase pain response, but heat induced pain like response was not inhibited significantly.
对热和化学刺激引起的疼痛反应有明显的镇痛作用。
The pain reactions induced by heat and chemical stimulus were significantly relieved by EMP.
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