外周神经损伤可分为开放性损伤和非开放性损伤。前者一般伴发于软组织的开放性损伤，引起神经的部分截断或全截断；后者并发于软组织的钝性非开放性损伤，引起神经干的挫伤、压迫或牵张，在神经内发生小的溢血和水肿，髓鞘水肿和变性。外周神经损伤的结果在临床上主要表现为神经麻痹。
Although intensivenerve research has shown that peripheral injury produces robust changes in the expression of numerous genes in primary sensory neurons, peripheral nerve injury-induced modification of genes in the dorsal horn remains largely unknown.
因此研究外周神经损伤后脊髓背角基因表达的变化对探索神经病理性疼痛的机制非常重要。
参考来源 - 腹腔注射氯胺酮及可乐定对慢性神经病理性疼痛模型大鼠的镇痛效应·2,447,543篇论文数据，部分数据来源于NoteExpress
组织损伤及外周神经损伤后可导致痛及痛过敏。
Pain and hyperalgesia was caused by injury of tissue and peripheral nerves.
然而，炎症进程也可影响外周神经损伤后的反应。
However, inflammatory processes may also contribute to peripheral nerve injury responses.
目的介绍壳聚糖在修复外周神经损伤中的研究现状。
Purpose To introduce the advances of chitosan in the repair of peripheral nerve injury.
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