基因置换就是用正常基因通过体内基因同源重组,原位替换病变细胞内的致病基因,使细胞内的DNA完全恢复正常状态
基因置换(gene replacement)是以大换血的方式将将整个致病基因替换为正常基因。理论上讲,基因修正与置换是目前最理想的基因治疗方式,但由于其中所需的同源...
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... 碱基置换;base replacement 基因置换;gene substitution 置换法;顶替法;排代法;displacement development ...
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根据针对宿主病变细胞基因采纳的办法不同,将基因疗治计谋分为: 基因置换 ( gene replcent ):指将致病基因整个地换以正常基因,使致病基因得到永久的更正。
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PCR介导的基因置换 PCR-mediated gene replacement
基因定位置换整合 targeted gene replacement and integration
基因平均置换时间 average gene substitution time
In this study, PCR-mediated gene replacement technique was applied in theconstruction nsdA gene disruption strain.
本研究采用了PCR介导的基因置换技术构建nsdA基因中断菌株。
参考来源 - nsdA基因中断及orfX基因整合表达对阿维链霉菌次级代谢的影响By using the gene replacement construct pHZ2029, approximate 80kb fragment from chromosome was substituted by an apramycin resistance gene (aac(3)IV) ofpHZ2029 through double crossing over by homologous recombination event.
通过基因置换获得缺失约80kb片段的突变菌株HJ5。
参考来源 - 抗生素FR·2,447,543篇论文数据,部分数据来源于NoteExpress
一种由深圳赛百诺基因技术公司――一家中国公司,所使用的方法就是用正常的肿瘤抑制基因置换破损的肿瘤抑制基因。
One approach, used by Shenzhen SiBiono GeneTech, a Chinese company, is to replace broken tumour-suppressor genes with the correct version.
科学家已经知道alk的异常和淋巴瘤还有肺癌的的发病有关。ALK的异常引起染色体之间DNA的置换,从而引起新的癌症基因的突变。
Scientists already knew that abnormalities in ALK were linked to lymphoma and lung cancer, where it triggers the translocation of DNA between chromosomes to make new cancer-causing genes.
最初大家都只知道它的序列很短,是极其微小的RNA控制片断,大家叫它为反义RNA,它通过置换作用而阻止抑制基因的活性,从而阻碍密码子的转录与翻译活动。
It was previously known that short, tiny control RNA, called antisense RNA, can stop the activity of genes by placing themselves so that "reading" of the code is impeded.
One way is to replace a gene that's defective in a disease.
其中之一是置换,导致某种疾病的缺陷基因
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