基因敲除技术是指通过一定的途径使机体特定的基因失活或缺失的技术。
基因敲除技术的广泛应用，极大地推动了后基因组时代对于基因功能研究的进程。
The widespread use of gene knockout technology promotes the course of the research of gene function in post genomic era greatly.
本文简述了基因敲除技术的基本原理、打靶策略、筛选机制，在动植物和微生物中常用的基因敲除方法以及基因敲除的应用。
This paper introduced the principle, the targeting strategies, the screening mechanism and the commonly method in animals, plants and micro-organisms of gene knockout.
这种基因敲除程序现在已经被普遍用于小鼠和大鼠，3名研究人员因为发明了这种“基因打靶”技术获得了2007年的诺贝尔奖。
These knockout procedures are now commonly done in mice and rats, and three researchers earned a Nobel prize in 2007 for developing this method, called "gene targeting".
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