噻唑烷二酮(TZD),口服降糖药(格列酮类),为胰岛素增敏剂,通过增加外周组织对胰岛素的敏感性、改善胰岛素抵抗而降低血糖,并能改善与胰岛素抵抗有关的多种心血管危险因素。该类药物应用过程中须密切注意肝功能。
噻唑烷二酮类药物吡格列酮盐酸盐的合成研究 关键词:重氮化;噻唑烷二酮;吡格列酮;合成 [gap=520]Key words:diazotization;thiazolidinedione;pioglitazone;synthesis
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常温清洗剂糖尿病肾病抗氧化剂治疗现状及展望 后经质子传递直接清除ros他汀类药物通过调脂以外的作用保护残存肾功能 4 噻唑烷二酮(tzd) 噻唑烷二酮(thiazolidine,tzd)是一类治疗2型糖尿病的新药,其主要机制为与位于肝脏、骨骼肌、脂肪组织等胰岛素靶器官上的过氧化物酶增殖
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噻唑烷二酮类 thiazolidinediones ; thiazolidine-diketone ; thiazolidinyldio- nes
噻唑烷二酮类药物 TZD ; thiazolidinediones ; Thiazoli dilsdioms ; thiazolidinedione compounds
4-噻唑烷二酮 Thiazolidinedione
配体噻唑烷二酮类 thiazolidinediones ; TZDS
噻唑烷二酮衍生物 TZD
最新的噻唑烷二酮 thiazolidinedione TZD
噻唑烷二酮类化合物 Thiazoliddinediones ; TZDS ; Thiazolidineline
噻唑烷二酮类降糖药 thizolidinedione ; TZD
属噻唑烷二酮 thiazolidines ; TZDS
And its structure is different from biguanides, sulfonylureas,α-glycosidase inhibitors,thiazolidinedione,GLP-1R peptide agonist drug which indicates that there is a different anti-diabetic mechanism and is an active leading compound worth studying.
该化合物与市售双胍类、磺脲类、α-糖苷酶抑制剂、噻唑烷二酮类以及GLP-1R激动剂肽类药物在结构上存在根本差异,则可能存在不同的作用机制,是具有较高开发价值的活性先导化合物。
参考来源 - 委陵菜黄酮药代动力学初步研究Total synthesis of the thiazolidinedione class of insulin-sensitizer rosiglitazone was studied. Rosiglitazone was synthesized simply and efficiently from 2-Chloropydine and 2-(Methyl amino)ethanol through 4 steps.
以2-氯吡啶和2-甲氨基乙醇为初始原料,经过4步反应合成出了噻唑烷二酮类胰岛素增敏剂罗格列酮。
参考来源 - 新型PPARγ受体激动剂的设计和合成·2,447,543篇论文数据,部分数据来源于NoteExpress
罗格列酮和吡咯列酮同属噻唑烷二酮类。
Rosiglitazone and pioglitazone are part of a group of drugs called thiazolidinediones.
您能就噻唑烷二酮在糖尿病治疗中的地位谈谈您的看法吗?
Could you express your view about the status of thiazolidinediones in treating diabetes?
噻唑烷二酮治疗非酒精性脂肪肝炎:继续,停止还是小心前行?
Thiazolidinedione therapy for nonalcoholic steatohepatitis: Go, stop, or proceed with caution?
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