在大鼠的中脑切片中利用盐或单剂量的可卡因进行处理并不能在腹侧被盖区诱发ltp的产生，只有在利用荷包牡丹碱或苦味毒减弱gaba(氨基丁酸)介导的抑制作用时才可以观察到LTP的出现。

In midbrain slices from rats treated with saline or a single dose of cocaine, LTP could not be induced in VTA dopamine neurons unless GABA-mediated inhibition was reduced by bicuculline or picrotoxin.

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此外，可卡因由机体代谢产生的多数产物（如诺可卡因及可卡乙碱）具有类似甚至更胜于可卡因的作用。

In addition, many of the metabolites of cocaine formed by the body (such as norcocaine and cocaethylene) have similar and sometimes stronger effects than cocaine itself.

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