化脓性链球菌是临床上最重要的链球菌，属A群、β溶血的链球菌。广泛存在于自然界和人及动物粪便和健康人鼻咽部，引起各种化脓性炎症，猩红热，丹毒，新生儿败血症，脑膜炎，产褥热以及链球菌变态反应性疾病等。
A群链球菌(Group A streptococcus,GAS)也称化脓性链球菌(Pyogenic streptococcus),是人类细菌感染最常见的病原菌之一,其引起的疾病约占人类链球菌感染的90%。
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化脓性链球菌可以产生许多的致病毒力因数，而过去已有许多相关研究。
S. pyogenes produces several virulence factors and many of them have been shown to contribute to its infection.
芯片已经被用来比较表现得到修改体外生长条件征收强调化脓性链球菌在快速增长。
Microarrays have been used to compare the expression profiles obtained by modifying in vitro growth conditions to impose stress on S. pyogenes during exponential growth.
虽然已知化脓性链球菌感染需要许多的致病因子参与其中，但是真正的细菌致病分子机转仍未被了解透彻。
Although there are many virulence factors that have shown to be involved in GAS infection, the actual molecular mechanism of bacterial pathogenesis in GAS is far from clear.
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