化疗指数(CI)是评价化疗药物安全性的指标。一般以动物半数致死量(LD50)和治疗感染动物的半数有效量(ED50)的比值表示。
聚合胶束作为抗癌药的载体具有靶向作用,可减少毒副作用,提高抗癌药物的化疗指数。
Polymeric micelles used as anticancer drug carriers show a few advantages in the improvement of drug-targeted release and chemotherapeutic efficacy, and the reduction of toxic effects of doxorubicin.
S72014对小白鼠的毒性比硝唑咪低达10倍,其化疗指数则高达硝唑咪的3.5倍。
S72014 was 10 times less toxic than niridazole and had a chemotherapeutic index 3.5 times as great.
结论核分裂指数和肿瘤体积是卵巢颗粒-间质细胞恶性肿瘤有价值的预后因素,而术后化疗并不改善患者的预后。
Conclusion Mitotic index and tumor size may be the valuable prognostic factors, however chemotherapy after operation can't improve the patients' survival.
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