初次应答指抗原初 次进入机体后,特异性B细胞经过活化、 增殖和分化过程成为浆细胞,合成抗体并释 放入血的过程。初次应答的显著特点是需要 的抗原浓度大、诱导潜伏期长、抗体滴度 低、持续时间短。M -抗原可刺激产生特异 性相同但Ig类别不同的抗体.一般是IgM 最先出现,滴度不高,消失也快。IgG出现 稍晚于IgM,当IgM接近消失时,IgG达高 峰阶段。产生抗体的亲和力也随时间经过IfiJ 加强。(赖江华)
So, these memory cells are a way that your immune system keeps track of antigens that it's been exposed to for even if maybe the plasma cells that were producing antibody in response to the initial exposure have died and disappeared.
所以,这些记忆细胞,是人体免疫系统记忆抗原的一种方法,即使由浆细胞产生的抗体,在初次免疫应答中全部被消灭,记忆细胞仍然能迅速分化为抗体分泌细胞
If we did the experiment where on this booster we included not only the initial antigen but some unrelated antigen, the response to the unrelated antigen called B here, looks like a primary response.
如果实验中我们使用的后续疫苗,不仅包括原抗原,还包括一些无关抗原,这里将对无关抗原的应答称为B,该应答就如同初次免疫一样
If you looked later, as the antibody production response matures, some IgG is produced so that in the late period after initial priming you'd have a mixture of IgM and IgG in the blood.
如果你稍后再观察,等到产生抗体的应答趋于成熟后,就会产生一些IgG抗体,在初次免疫的最终阶段,你的血液中有IgM,和IgG两种抗体
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