目的：探讨CD44单克隆抗体A3D8对人急性髓系白血病细胞株HL-60细胞增殖分化影响的分子作用机制。
Objective:To investigate the molecular mechanism of the effect of A3D8, an anti-CD44 monoclonal antibody on proliferation and differentiation of human HL-60 cells.
结论端粒酶活化与肿瘤的恶性转化密切相关，可作为恶性血液病恶性克隆增殖的分子标志，有希望成为监测微量残留白血病的一个新指标。
Conclusions Telomerase activity could be a useful marker for evaluating malignant clonal proliferation, and it is hopeful to become a new molecular target for monitoring minimal residual leukemia.
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