共刺激分子是参与共刺激信号传递的分子。共刺激信号影响到T淋巴细胞和B淋巴细胞的活化，不可或缺。
共刺激信号（costimulatory signals）及共刺激分子（costimulatory molecules）是1970年由Bresteher和Cohn在T细胞激活双信号学说的基础上首先提出并证实的…，新的共刺激分子成员不断地被发现、克隆。
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...共刺激分子；免疫低反应性 [gap=1774] colony-stimulating factor; peripheral blood stem cell graft; bone marrow graft; immunohy-poresponsiveness; costimulatory molecules ..
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共刺激分子(Co-stimulator)在淋巴细胞的激活和行使效应功能中发挥重要的调节作用,国内研究表明PD-1 (programmed death1)在肝衰竭患者特异性细胞毒性T细胞(c...
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可诱导共刺激分子 ICOS ; inducible costimulator ; inducible costimulatory molecule
诱导共刺激分子 ICOS
诱导性共刺激分子 ICOS ; inducible costimulator
可诱导共刺激分子配体 ICOSL ; inducible co-stimulator ligand ; I-COSL
性共刺激分子 inducible costimulator ; ICOS
细胞共刺激分子 Inducible T cellcostimulator ; ICOS
等共刺激分子 Costimulatory molecules
共刺激分子配体 inducible co-stimulator lig-and
称为共刺激分子 costimulatory molecules
T cells cannot activate, proliferate and differeriate without costimulatory molecules . Autoimmune diseases will occur when costimulatory molecules express abnormally.
若缺乏共刺激分子，T细胞不能获得有效地活化、增殖、分化，介导细胞免疫功能；若共刺激分子过度表达，则可激活自身反应性T细胞，导致自身免疫性疾病。
参考来源 - 慢性肾小球肾炎免疫病理机制的探讨Objective:To study the expression of co-stimulatory molecule B7-H3 and matrix metalloproteinase-2(MMP-2) in endometrial precancerous lesions and endometrial carcinoma,and to analyze its expression in endometrial carcinoma relevance as well as the relationship between clinicopathological features.
目的:研究共刺激分子B7-H3和基质金属蛋白酶-2(MMP-2)在子宫内膜癌前病变及子宫内膜癌组织中的表达情况,分析其在子宫内膜癌中表达的相关性以及与临床病理特征的关系。
参考来源 - B7However, inhibitory costimulatory factors could be involved in the pathogenesis in two ways by inducing T cell anergy: inducing inhibitory cofactor expression in effector immune cells or expression of ligands of inhibitory cofactor on tumor cells.
负性共刺激分子通过两种方法来诱导T细胞无力：一是诱导抑制性因子表达在效应性免疫细胞上，二是诱导抑制性因子受体表达在肿瘤细胞上。
参考来源 - 共刺激分子B7·2,447,543篇论文数据，部分数据来源于NoteExpress
目的探讨共刺激分子在哮喘发病免疫学机制中的作用。
Objective to investigate the potential role of co-stimulators in the immunological mechanism of asthma.
已有研究表明，共刺激分子的表达与同种异体移植排斥反应有关。
It has been showed that the expressions of costimulatory molecules are associated with xero organ transplantation rejection.
可见，肿瘤细胞上共刺激分子缺陷是肿瘤免疫逃逸的重要机制之一。
Therefore, deficiency of costimulatory molecules on tumor cells is one of the important mechanisms of tumor immune escape.
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