因为得长期依赖轮椅行动，他和外界隔绝，待在自己的房间里；
Permanently wheelchair-bound, Jian shied from the outside world and confined himself to his room.
霍金患有肌萎缩性脊髓侧索硬化症，简称ALS，他只能坐在轮椅上，说话必须依赖电脑语音发生器。
Hawking has ALS, or amyotrophic lateral sclerosis, which has confined him to a wheelchair and leaves him unable to speak without the help of a computerized voice synthesizer.
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