The mechanism of drug-resistance of Escherichia coli is quite complex,mainly including the creation of antibiotics inactivated enzyme,changing the role of drug target site,decreased expression of outer membrane porins and overexpression of multidrug efflux pumps.
大肠埃希菌对常用抗菌药物的耐药机制相当复杂,主要包括产生灭活抗生素的酶、改变药物作用靶位、细胞外膜通透性的改变及细菌药物外排泵。
参考来源 - 大肠埃希菌耐药机制研究进展·2,447,543篇论文数据，部分数据来源于NoteExpress
经证明很难确定先前未知的抗菌素作用靶位。
The identification of previously unknown target sites for antimicrobial action has proved difficult.
此外，实验结果还提示不同作用靶位的A SODN之间具有一定的协同作用。
In addition, the results also indicated that there were some coordinate effects between ASODNs at different targets.
线粒体是真核生物中拥有蛋白和酶最多的细胞器，因而隐孢子虫线粒体也可能成为药物潜在的作用靶位。
Mitochondrion is an organelle which contains most protein and enzyme in eukaryotes, so the mitochondrion of Cryptosporidium may be a potential target of drugs.
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