为了论证这点，Baker和van Deursen繁殖了一组具有快速衰老基因的实验鼠，在这个过程中，对实验鼠施以药物刺激，从而清除脂肪组织、肌肉和眼睛中含有P16的细胞。

To accomplish this, Baker and van Deursen designed a fast-aging mouse strain that would, upon receiving a drug trigger, expel p16-producing cells from fatty tissues, muscles and eyes.

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